The tranquilizer farmapram (alprazolam)

farmapram

The drug farmapram has the active ingredient alprazolam, which is a tranquilizer. It is used for anxiety and neurosis with anxiety, tension, restlessness, irritability, sleep disturbance, somatic disorders. Anxiety associated with depression (as part of complex therapy). Panic disorders (treatment). Tremor (senile, essential). Insomnia.

Pharmacological action

The tranquilizer farmapram (alprazolam)

Anxiolytic medicine (tranquilizer), a derivative of triazole-benzodiazepine. It has anxiolytic, sedative, hypnotic, anticonvulsant, central myorelaxant action. The mechanism of action is to increase inhibitory effects of endogenous GABA in CNS by increasing sensitivity of GABA receptors to the mediator through stimulation of benzodiazepine receptors located in the allosteric center of postsynaptic GABA receptors in the ascending activating reticular formation of the brain stem and the insertion neurons of the lateral horns of the spinal cord; reduces excitability of subcortical structures of the brain (limbic system, thalamus, hypothalamus), inhibits polysynaptic spinal reflexes.

Expressed anxiolytic activity (reduction of emotional tension, easing of anxiety, fear, restlessness) is combined with a moderately pronounced hypnotic effect; it shortens the period of falling asleep, increases the duration of sleep, reduces the number of night awakenings. The mechanism of sleeping pills is inhibition of the reticular formation cells of the brain stem. It reduces the impact of emotional, vegetative and motor stimuli that disturb the mechanism of falling asleep.

Pharmacokinetics

After oral administration, Farmapram (alprazolam) is rapidly and completely absorbed from the gastrointestinal tract. Cmax in plasma is reached within 1-2 hours. Binding to plasma proteins is 80%. It is metabolized in the liver. T1/2 is on average 12-15 hours. Alprazolam and its metabolites are excreted mainly by the kidneys.

Indications for use of the drug Farmapram (Alprazolam)

The tranquilizer farmapram (alprazolam)

Anxiety, neurosis accompanied by anxiety, danger, restlessness, tension, sleep disturbance, irritability as well as somatic disorders; mixed anxiety-depressive states; neurotic reactive-depressive states accompanied by depressed mood, loss of interest in others, restlessness, sleep loss, reduced appetite and somatic disorders; states of anxiety and neurotic depression in combination with somatic diseases; panic disorders with or without symptoms.

Contraindications to use

Coma, shock, myasthenia gravis, closed-angle glaucoma (acute attack or predisposition), acute alcohol poisoning (with weakening of vital functions), opioid analgesics, sleeping pills and psychotropic drugs, chronic obstructive respiratory diseases with initial manifestations of respiratory failure acute respiratory failure, severe depression (suicidal tendencies may occur), pregnancy (especially I trimester), lactation, childhood and adolescence under 18 years of age, hypersensitivity to benzodiazepines.